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Current research projects

High Impact Research 03

 

1. Constructing the cancer progression model: The identification of key players in malignant transformation (MOE HIR 03)

 

Principal Investigator(PI): Prof Dato’ Dr Zainal Ariff Abdul Rahman (zainalr@um.edu.my)

Co-PI: Adjunct Prof Dr Cheong Sok Ching (sokching.cheong@carif.com.my)

 

Project Synopsis: The project objectives include:

 

-studying the clinical determinants of outcome for potentially malignant lesions amongst Malaysian patients.

-identifying changes in the epithelial and stromal compartments in premalignant lesions that progressed to oral squamous cell carcinoma compared to those that remained as premalignant lesions.

-using a systems biology approach, we propose to identify genes with maximum biological significance in the malignant transformation process.

-determining the diagnostic and prognostic significance of the gene expression data in an independent samples.

-developing premalignant cell lines as in vitro models.

 

High Impact Research 06

 

2. Biobanking of oral cancers: An assessment of survival, clinicopathological parameters, management strategies, nutrition and genetic susceptibility of patients (MOE HIR 06)

 

Principal Investigator(PI): Prof Dr Rosnah Mohd Zain (rosnahmz@um.edu.my)

Co-PI: Prof Dato' Dr Zainal Ariff Abdul Rahman (zainalr@um.edu.my)

 

Project Synopsis: The project objectives include:

 

-utilizing collected sociodemographic, clinicopathologic, nutrition, management, survival and follow-up data in association studies on oral cancer.

-studies on oral cancer and genetic susceptibility.

-maintained tissue and databank to support all types of research related to oral cancer.

 

High Impact Research 08

 

3. Cancer specific genomic duplications and deletions, validation of differentially expressed genes and single nucleotide polymorphisms (SNPs) studies and protein array analysis: possible prognostic tools (MOE HIR 8)

 

Principal Investigator(PI): Prof Dr Rosnah Mohd Zain (rosnahmz@um.edu.my)

Co-PI: Dr Siti Mazlipah Ismail (sitimazlipah@um.edu.my)

 

Project Synopsis: The project objectives include:

 

-identifying CNVs in oral cancer using aCGH.

-validating known and novel differentially expressed genes in oral cancer & to characterize the candidate gene(s) in the downstream application using functional assays.

-validating tumor associated antigens from the protein array using ELISA/Western Blot.

 

High Impact Research 10

 

4. Nutrigenomics and phospholipid signalling in oral cancer: Nutrient –gene interactions. (MOE HIR 10)

 

Principal Investigator(PI): Prof Dr Ian Paterson (ipaterson@um.edu.my)

Co-PI: Dr Yap Lee Fah (yapleefah@um.edu.my)

 

Project Synopsis: The project objectives include:

 

-investigating gene expression differences between normal and tumour cells, with a focus on nutrient and lipid signalling pathways.

-examining the contribution of bioactive lipid signalling pathways to the development and progression of oral cancer.

-determining the therapeutic potential of targeting phospholipid signaling pathways for the treatment of oral cancer.

 

High Impact Research 22

 

5. Oncogenesis of head and neck cancer. Mechanisms of oral carcinogenesis: From homeostasis to drug discovery (MOE HIR 22)

 

Principal Investigator(PI): Prof Dr Ian Paterson (ipaterson@um.edu.my)

Co-PI: Dr Yap Lee Fah (yapleefah@um.edu.my)

 

Project Synopsis: The overarching aims of this study are to study the mechanisms associated with oral epithelial homeostasis and carcinogenesis, and to develop novel therapeutic drugs for oral cancer. Sub-projects include:

 

-examining the molecular mechanisms associated with epithelial homeostasis and how they are altered in oral carcinogenesis.

-investigating the role of cancer associated senescent fibroblasts in the development and progression of oral cancer.

-developing inhibitors of key cell signalling pathways as potential therapeutic drugs.

 

High Impact Research 23

 

6. Oncogenesis of head and neck cancer: Contribution of Epstein-Barr Virus (EBV), cellular signalling pathways and driver mutations to the pathogenesis of nasopharyngeal carcinoma (NPC) (MOE HIR 23)

 

Principal Investigator(PI): Dr Yap Lee Fah (yapleefah@um.edu.my)

Co-PI: Prof Dr Ian Paterson (ipaterson@um.edu.my)

 

Project Synopsis: The overarching aims of this study are to elucidate the molecular mechanisms associated with the pathogenesis of NPC and to understand the role of EBV in the disease progression. Sub-projects include:

 

-aberrant lipid signaling: tumorigenesis, EBV infection and tumour microenvironment.

-TGF-β signaling pathway in the regulation of EBV infection.

-Deciphering the mutational landscape of NPC.

 

High Impact Research 24

 

4. Early detection of oral potentially malignant disorders (OPMD) and malignant oral mucosal lesions - Preventive, clinical and molecular approaches (MOE HIR 24)

 

Principal Investigator(PI): Dr Siti Mazlipah Ismail (sitimazlipah@um.edu.my)

Co-PI: Prof Dr Rosnah Mohd Zain (rosnahmz@um.edu.my)

 

Project Synopsis: The project objectives include:

 

-determining the accuracy of optical diagnostic tests/techniques, brush biopsy with DNA content analysis for the early detection of OPMD.

-determining the prevalence of HPV 16 and related molecular changes on the sample population with oral cancer.

-determining the effect of oral health education (OHE) intervention program on the sample population and to assess the feasibility of using peer support group in raising oral cancer awareness.


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